F4-03-03: SELECTIVITY OF PET AMYLOID IMAGING LIGANDS IN THE ALZHEIMER'S DISEASE NEUROPATHOLOGY SPECTRUM

Amyloid PET imaging: applications beyond Alzheimer’s disease

As a biomarker of beta-amyloid, positron emission tomography (PET) amyloid imaging offers a unique opportunity to detect the presence of this protein in the human body during life. Besides Alzheimer's disease (AD), deposits of beta-amyloid in the brain are also present in other neurodegenerative diseases associated to dementia, such as Parkinson's disease and dementia with Lewy bodies, as well ...

Amyloid Imaging PET Ligands as Biomarkers for Alzheimer’s Disease, Preclinical Evaluation

Carbonylations and Radiosynthesis of Amyloid PET Ligands

Nordeman, P. 2014. Development of Palladium-Promoted C/C-Carbonylations and Radiosynthesis of Amyloid PET Ligands. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 183. 76 pp. Uppsala: Uppsala universitet. ISBN 978-91-554-8843-7. In the first part of this thesis, palladium(0)-catalyzed and -mediated carbonylations are discussed. Paper I describes a new metho...

Segmentation of Alzheimers Disease in PET scan datasets using MATLAB

Positron Emission Tomography (PET) scan images are one of the bio medical imaging techniques similar to that of MRI scan images but PET scan images are helpful in finding the development of tumors. The PET scan images requires expertise in the segmentation where clustering plays an important role in the automation process. The segmentation of such images is manual to automate the process cluste...

Amyloid brain PET imaging

Brain positron emission tomography (PET) has also been used over many years to diagnose neurodegenerative diseases, and has advantages over MRI due to its higher sensitivity to detect pathologies at a molecular level. While 18F-fluorodeoxyglucose (FDG) PETCT is an established imaging technique for assisting in the differential diagnosis of Alzheimer’s disease (AD) and other forms of dementia, P...